Hypoxia induces re-entry of committed cells into pluripotency

Adult stem cells reside in hypoxic niches and embryonic stem cells (ESCs) are derived from a low oxygen environment. However, it is not clear whether hypoxia is critical for stem cell fate since for example human ESCs (hESCs) are able to self-renew in atmospheric oxygen concentrations as well. We no...

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Bibliographic Details
Main Authors:	Mathieu, Julie, Zhang, Zhan, Nelson, Angelique, Lamba, Deepak A., Reh, Thomas A., Ware, Carol, Ruohola-Baker, Hannele
Format:	Artigo
Language:	Inglês
Published:	2013
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3921075/ https://ncbi.nlm.nih.gov/pubmed/23765801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1446
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Hypoxia induces re-entry of committed cells into pluripotency

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