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Hypoxia Inducible Factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency
Pluripotent stem cells have distinct metabolic requirements, and reprogramming cells to pluripotency requires a shift from oxidative to glycolytic metabolism. Here, we show that this shift occurs early during reprogramming of human cells and requires Hypoxia Inducible Factors in a stage-specific man...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4028142/ https://ncbi.nlm.nih.gov/pubmed/24656769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.02.012 |
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