Hypoxia Inducible Factors have distinct and stage-specific roles during reprogramming of human cells to pluripotency

Pluripotent stem cells have distinct metabolic requirements, and reprogramming cells to pluripotency requires a shift from oxidative to glycolytic metabolism. Here, we show that this shift occurs early during reprogramming of human cells and requires Hypoxia Inducible Factors in a stage-specific man...

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Main Authors: Mathieu, Julie, Zhou, Wenyu, Xing, Yalan, Sperber, Henrik, Ferreccio, Amy, Agoston, Zsuzsa, Kuppusamy, Kavitha T, Moon, Randall T, Ruohola-Baker, Hannele
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028142/
https://ncbi.nlm.nih.gov/pubmed/24656769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2014.02.012
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