Immunoglobulin heavy chain toxicity in plasma cells is neutralized by fusion to pre-B cells.
A plasma cell hybridoma frequently loses its immunoglobulin heavy (H) chain spontaneously but rarely is production of its light (L) chain lost. Upon fusion to a pre-B-cell hybridoma that produces no Ig chain, the L chain is frequently lost. In cells without the L chain the H chain, which is derived...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
1984
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC392102/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6438634/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.22.7185 |
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