Enhanced silencing and stabilization of siRNA polyplexes by histidine-mediated hydrogen bonds

Branched peptides containing histidines and lysines (HK) have been shown to be effective carriers for DNA and siRNA. We anticipate that elucidation of the binding mechanism of HK with siRNA will provide greater insight into the self-assembly and delivery of the HK:siRNA polyplex. Non-covalent bonds...

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Main Authors: Chou, Szu-Ting, Hom, Kellie, Zhang, Daoning, Leng, Qixin, Tricoli, Lucas J., Hustedt, Jason M., Lee, Amy, Shapiro, Michael J., Seog, Joonil, Kahn, Jason D., Mixson, A. James
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920840/
https://ncbi.nlm.nih.gov/pubmed/24161165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2013.10.019
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