Lateral Clustering of TLR3:dsRNA Signaling Units Revealed by TLR3ecd:3Fabs Quaternary Structure

Toll-like receptor 3 (TLR3) recognizes dsRNA and initiates an innate immune response through the formation of a signaling unit (SU) composed of one double-stranded RNA (dsRNA) and two TLR3 molecules. We report the crystal structure of human TLR3 ectodomain (TLR3ecd) in a quaternary complex with thre...

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Détails bibliographiques
Auteurs principaux: Luo, Jinquan, Obmolova, Galina, Malia, Thomas J., Wu, Sheng-Jiun, Duffy, Karen E., Marion, James D., Bell, Jessica K., Ge, Peng, Zhou, Z. Hong, Teplyakov, Alexey, Zhao, Yonghong, Lamb, Roberta J., Jordan, Jarrat L., San Mateo, Lani R., Sweet, Raymond W., Gilliland, Gary L.
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920545/
https://ncbi.nlm.nih.gov/pubmed/22579623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.05.006
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