Knockdown of RNF2 induces apoptosis by regulating MDM2 and p53 stability

RNF2, also known as Ring1B/Ring2, is a component of the polycomb repression complex 1 (PRC1). RNF2 is highly expressed in many tumors, suggesting that it might have an oncogenic function, but the mechanism is unknown. Here we show that knockdown of RNF2 significantly inhibits both cell proliferation...

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Autori principali: Wen, Weihong, Peng, Cong, Kim, Myoung Ok, Jeong, Chul Ho, Zhu, Feng, Yao, Ke, Zykova, Tatyana, Ma, Weiya, Carper, Andria, Langfald, Alyssa, Bode, Ann M., Dong, Zigang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920452/
https://ncbi.nlm.nih.gov/pubmed/23318437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.605
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