ENaC activity is increased in isolated, split-open cortical collecting ducts from protein kinase Cα knockout mice

The epithelial Na channel (ENaC) is negatively regulated by protein kinase C (PKC) as shown using PKC activators in a cell culture model. To determine whether PKCα influences ENaC activity in vivo, we examined the regulation of ENaC in renal tubules from PKCα(−/−) mice. Cortical collecting ducts wer...

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Bibliographic Details
Main Authors: Bao, Hui-Fang, Thai, Tiffany L., Yue, Qiang, Ma, He-Ping, Eaton, Amity F., Cai, Hui, Klein, Janet D., Sands, Jeff M., Eaton, Douglas C.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920049/
https://ncbi.nlm.nih.gov/pubmed/24338818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00519.2013
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