Activation of Signaling Pathways Following Localized Delivery of Systemically-Administered Neurotrophic Factors across the Blood-Brain Barrier Using Focused Ultrasound and Microbubbles

The brain-derived neurotrophic factor (BDNF) has been shown to have broad neuroprotective effects in addition to its therapeutic role in neurodegenerative disease. In this study, the efficacy of delivering exogenous BDNF to the left hippocampus is demonstrated in wild-type mice (n=7) through the non...

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Main Authors: Baseri, Babak, Choi, James J., Deffieux, Thomas, Samiotaki, Mania, Tung, Yao-Sheng, Olumolade, Oluyemi, Small, Scott A., Morrison, Barclay, Konofagou, Elisa E.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919955/
https://ncbi.nlm.nih.gov/pubmed/22407323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1088/0031-9155/57/7/N65
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