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A single residue in the M2-M3 loop is a major determinant of coupling between binding and gating in neuronal nicotinic receptors.

Binding of agonists to nicotinic acetylcholine receptors generates a sequence of changes that activate a cation-selective conductance. By measuring electrophysiological responses in chimeric alpha7/alpha3 receptors expressed in Xenopus oocytes, we have showed the involvement of the M2-M3 loop in cou...

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Bibliografiske detaljer
Main Authors: Campos-Caro, A, Sala, S, Ballesta, J J, Vicente-Agulló, F, Criado, M, Sala, F
Format: Artigo
Sprog:Inglês
Udgivet: 1996
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC39199/
https://ncbi.nlm.nih.gov/pubmed/8650229
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