Liver-Specific γ-Glutamyl Carboxylase-Deficient Mice Display Bleeding Diathesis and Short Life Span

Vitamin K is a fat-soluble vitamin that plays important roles in blood coagulation and bone metabolism. One of its functions is as a co-factor for γ-glutamyl carboxylase (Ggcx). Conventional knockout of Ggcx causes death shortly after birth in homozygous mice. We created Ggcx-floxed mice by insertin...

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Detalhes bibliográficos
Main Authors: Azuma, Kotaro, Tsukui, Tohru, Ikeda, Kazuhiro, Shiba, Sachiko, Nakagawa, Kimie, Okano, Toshio, Urano, Tomohiko, Horie-Inoue, Kuniko, Ouchi, Yasuyoshi, Ikawa, Masahito, Inoue, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919827/
https://ncbi.nlm.nih.gov/pubmed/24520408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088643
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