Vitamin K-Dependent γ-Glutamyl Carboxylase in Sertoli Cells Is Essential for Male Fertility in Mice

γ-Glutamyl carboxylase (GGCX) is a vitamin K (VK)-dependent enzyme that catalyzes the γ-carboxylation of glutamic acid residues in VK-dependent proteins. The anticoagulant warfarin is known to reduce GGCX activity by inhibiting the VK cycle and was recently shown to disrupt spermatogenesis. To explo...

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Udgivet i:Mol Cell Biol
Main Authors: Shiba, Sachiko, Ikeda, Kazuhiro, Horie-Inoue, Kuniko, Azuma, Kotaro, Hasegawa, Tomoka, Amizuka, Norio, Tanaka, Tomoaki, Takeiwa, Toshihiko, Shibata, Yasuaki, Koji, Takehiko, Inoue, Satoshi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2021
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8088131/
https://ncbi.nlm.nih.gov/pubmed/33526452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00404-20
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