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Therapeutic reversal of chronic alcohol-related steatohepatitis with the ceramide inhibitor myriocin
Alcohol-related liver disease (ALD) is associated with steatohepatitis and insulin resistance. Insulin resistance impairs growth and disrupts lipid metabolism in hepatocytes. Dysregulated lipid metabolism promotes ceramide accumulation and oxidative stress, leading to lipotoxic states that activate...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Blackwell publishing Ltd
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3919649/ https://ncbi.nlm.nih.gov/pubmed/24456332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/iep.12052 |
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