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Therapeutic reversal of chronic alcohol-related steatohepatitis with the ceramide inhibitor myriocin
Alcohol-related liver disease (ALD) is associated with steatohepatitis and insulin resistance. Insulin resistance impairs growth and disrupts lipid metabolism in hepatocytes. Dysregulated lipid metabolism promotes ceramide accumulation and oxidative stress, leading to lipotoxic states that activate...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3919649/ https://ncbi.nlm.nih.gov/pubmed/24456332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/iep.12052 |
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