Hepatic Ceramide May Mediate Brain Insulin Resistance and Neurodegeneration in Type 2 Diabetes and Non-alcoholic Steatohepatitis

Obesity, type 2 diabetes mellitus (T2DM), and non-alcoholic steatohepatitis (NASH) can be complicated by cognitive impairment and neurodegeneration. Experimentally, high fat diet (HFD)-induced obesity with T2DM causes mild neurodegeneration with brain insulin resistance. Since ceramides are neurotox...

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Detalhes bibliográficos
Main Authors: Lyn-Cook, Lascelles E., Lawton, Margot, Tong, Ming, Silbermann, Elizabeth, Longato, Lisa, Jiao, Ping, Mark, Princess, Wands, Jack R., Xu, Haiyan, de la Monte, Suzanne M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893047/
https://ncbi.nlm.nih.gov/pubmed/19387108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2009-0984
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