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Islets of Langerhans from prohormone convertase-2 knockout mice show α-cell hyperplasia and tumorigenesis with elevated α-cell neogenesis

Antagonism of the effects of glucagon as an adjunct therapy with other glucose-lowering drugs in the chronic treatment of diabetes has been suggested to aggressively control blood glucose levels. Antagonism of glucagon effects, by targeting glucagon secretion or disabling the glucagon receptor, is a...

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Detalhes bibliográficos
Main Authors: Jones, Huw B, Reens, Jaimini, Brocklehurst, Simon R, Betts, Catherine J, Bickerton, Sue, Bigley, Alison L, Jenkins, Richard P, Whalley, Nicky M, Morgan, Derrick, Smith, David M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell publishing Ltd 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919648/
https://ncbi.nlm.nih.gov/pubmed/24456331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/iep.12066
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