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Quantitation of DNA double-strand break resection intermediates in human cells
5′ strand resection at DNA double strand breaks (DSBs) is critical for homologous recombination (HR) and genomic stability. Here we develop a novel method to quantitatively measure single-stranded DNA intermediates in human cells and find that the 5′ strand at endonuclease-generated break sites is r...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3919611/ https://ncbi.nlm.nih.gov/pubmed/24362840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1309 |
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