Cellular senescence mediated by p16(INK4A)-coupled miRNA pathways

p16 is a key regulator of cellular senescence, yet the drivers of this stable state of proliferative arrest are not well understood. Here, we identify 22 senescence-associated microRNAs (SA-miRNAs) in normal human mammary epithelial cells. We show that SA-miRNAs-26b, 181a, 210 and 424 function in co...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Overhoff, Marita G., Garbe, James C., Koh, James, Stampfer, Martha R., Beach, David H., Bishop, Cleo L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2014
Aiheet:
Gene Regulation, Chromatin and Epigenetics
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919591/
https://ncbi.nlm.nih.gov/pubmed/24217920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1096
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