The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans

BACKGROUND: Cellular senescence is a stable arrest of proliferation and is considered a key component of processes associated with carcinogenesis and other ageing-related phenotypes. Here, we perform methylome analysis of actively dividing and deeply senescent normal human epithelial cells. RESULTS:...

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Foilsithe in:Genome Biol
Main Authors: Lowe, Robert, Overhoff, Marita G., Ramagopalan, Sreeram V., Garbe, James C., Koh, James, Stampfer, Martha R., Beach, David H., Rakyan, Vardhman K., Bishop, Cleo L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2015
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574115/
https://ncbi.nlm.nih.gov/pubmed/26381124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0748-4
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