An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity

SREBPs are key transcriptional regulators of lipid metabolism and cellular growth. It has been proposed that SREBP signaling regulates cellular growth through its ability to drive lipid biosynthesis. Unexpectedly, we find that loss of SREBP activity inhibits cancer cell growth and viability by uncou...

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Bibliographic Details
Main Authors: Williams, Kevin J., Argus, Joseph P., Zhu, Yue, Wilks, Moses Q., Marbois, Beth N., York, Autumn G., Kidani, Yoko, Pourzia, Alexandra L., Akhavan, David, Lisiero, Dominique N., Komisopoulou, Evangelia, Henkin, Amy H., Soto, Horacio, Chamberlain, Brian T., Vergnes, Laurent, Jung, Michael E., Torres, Jorge Z., Liau, Linda M., Christofk, Heather R., Prins, Robert M., Mischel, Paul S., Reue, Karen, Graeber, Thomas G., Bensinger, Steven J.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919498/
https://ncbi.nlm.nih.gov/pubmed/23440422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-0382-T
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