SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression

Cholesterol and fatty acid biosynthesis are regulated by the sterol regulatory element-binding proteins (SREBPs), encoded by Srebf1 and Srebf2. We generated mice that were either deficient or hypomorphic for SREBP-2. SREBP-2 deficiency generally caused death during embryonic development. Analyses of...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Vergnes, Laurent, Chin, Robert G., de Aguiar Vallim, Thomas, Fong, Loren G., Osborne, Timothy F., Young, Stephen G., Reue, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4766990/
https://ncbi.nlm.nih.gov/pubmed/26685326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M064022
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