A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration.
We have used site-directed mutagenesis of cloned Moloney murine leukemia virus (MuLV) DNA to define a function encoded in the 3' region of the viral pol gene and required for efficient integration of viral DNA. One mutant, MuLV-SF1, contained a single base substitution (C to T at base 4950) that res...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1984
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391944/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6208550/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.20.6461 |
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