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A mutant murine leukemia virus with a single missense codon in pol is defective in a function affecting integration.

We have used site-directed mutagenesis of cloned Moloney murine leukemia virus (MuLV) DNA to define a function encoded in the 3' region of the viral pol gene and required for efficient integration of viral DNA. One mutant, MuLV-SF1, contained a single base substitution (C to T at base 4950) tha...

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Autors principals: Donehower, L A, Varmus, H E
Format: Artigo
Idioma:Inglês
Publicat: 1984
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC391944/
https://ncbi.nlm.nih.gov/pubmed/6208550
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