Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation

Ras superfamily GTPase activation and inactivation occur by canonical nucleotide exchange and GTP hydrolysis mechanisms. Despite conservation of active-site residues, the Ras-related Rab GTPase activation pathway differs from Ras and between different Rabs. Analysis of DENND1-Rab35, Rabex-Rab5, TRAP...

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Bibliografiska uppgifter
Huvudupphovsmän: Langemeyer, Lars, Nunes Bastos, Ricardo, Cai, Yiying, Itzen, Aymelt, Reinisch, Karin M, Barr, Francis A
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2014
Ämnen:
Biochemistry
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919270/
https://ncbi.nlm.nih.gov/pubmed/24520163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01623
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