Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation

Ras superfamily GTPase activation and inactivation occur by canonical nucleotide exchange and GTP hydrolysis mechanisms. Despite conservation of active-site residues, the Ras-related Rab GTPase activation pathway differs from Ras and between different Rabs. Analysis of DENND1-Rab35, Rabex-Rab5, TRAP...

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Bibliografske podrobnosti
Main Authors: Langemeyer, Lars, Nunes Bastos, Ricardo, Cai, Yiying, Itzen, Aymelt, Reinisch, Karin M, Barr, Francis A
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2014
Teme:
Biochemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919270/
https://ncbi.nlm.nih.gov/pubmed/24520163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01623
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