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Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate
Rab GTPases are key regulators of membrane traffic pathways within eukaryotic cells. They are specifically activated by guanine nucleotide exchange factors (GEFs), which convert them from their “inactive” GDP-bound form to the “active” GTP-bound form. In higher eukaryotes, proteins containing DENN-d...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3219131/ https://ncbi.nlm.nih.gov/pubmed/22065758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110415108 |
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