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Cross-sectional and longitudinal changes in DNA methylation with age: an epigenome-wide analysis revealing over 60 novel age-associated CpG sites

Understanding the role of epigenetic modifications, e.g. DNA methylation, in the process of aging requires the characterization of methylation patterns in large cohorts. We analysed >480 000 CpG sites using Infinium HumanMethylation450 BeadChip (Illumina) in whole blood DNA of 965 participants of...

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Библиографические подробности
Главные авторы: Florath, Ines, Butterbach, Katja, Müller, Heiko, Bewerunge-Hudler, Melanie, Brenner, Hermann
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919014/
https://ncbi.nlm.nih.gov/pubmed/24163245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt531
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