Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: a study using genetically encoded FRET-based reporters

Carney complex (CNC) is a hereditary disease associating cardiac myxoma, spotty skin pigmentation and endocrine overactivity. CNC is caused by inactivating mutations in the PRKAR1A gene encoding PKA type I alpha regulatory subunit (RIα). Although PKA activity is enhanced in CNC, the mechanisms linki...

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Detalhes bibliográficos
Main Authors: Cazabat, Laure, Ragazzon, Bruno, Varin, Audrey, Potier-Cartereau, Marie, Vandier, Christophe, Vezzosi, Delphine, Risk-Rabin, Marthe, Guellich, Aziz, Schittl, Julia, Lechêne, Patrick, Richter, Wito, Nikolaev, Viacheslav O., Zhang, Jin, Bertherat, Jérôme, Vandecasteele, Grégoire
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919008/
https://ncbi.nlm.nih.gov/pubmed/24122441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddt510
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