Structure of sugar-bound LacY

Here we describe the X-ray crystal structure of a double-Trp mutant (Gly46→Trp/Gly262→Trp) of the lactose permease of Escherichia coli (LacY) with a bound, high-affinity lactose analog. Although thought to be arrested in an open-outward conformation, the structure is almost occluded and is partially...

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Main Authors: Kumar, Hemant, Kasho, Vladimir, Smirnova, Irina, Finer-Moore, Janet S., Kaback, H. Ronald, Stroud, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918835/
https://ncbi.nlm.nih.gov/pubmed/24453216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1324141111
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