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The roles of counterion and water in a stereoselective cysteine-catalyzed Rauhut-Currier reaction: A challenge for computational chemistry

The stereoselective Rauhut-Currier (RC) reaction catalyzed by a cysteine derivative has been explored computationally with DFT (M06-2X) theory. Both methanethiol and a chiral cysteine derivative were studied as nucleophiles. The complete reaction pathway involves rate-determining elimination of the...

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Detalhes bibliográficos
Main Authors: Osuna, Sílvia, Dermenci, Alpay, Miller, Scott J., Houk, K. N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918516/
https://ncbi.nlm.nih.gov/pubmed/24038400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201300745
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