Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System

The spatiotemporal organization and dynamics of chromatin play critical roles in regulating genome function. However, visualizing specific, endogenous genomic loci remains challenging in living cells. Here, we demonstrate such an imaging technique by repurposing the bacterial CRISPR/Cas system. Usin...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Chen, Baohui, Gilbert, Luke A., Cimini, Beth A., Schnitzbauer, Joerg, Zhang, Wei, Li, Gene-Wei, Park, Jason, Blackburn, Elizabeth H., Weissman, Jonathan S., Qi, Lei S., Huang, Bo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918502/
https://ncbi.nlm.nih.gov/pubmed/24360272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.12.001
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