Saturation mutagenesis of selected residues of the α-peptide of the lantibiotic lacticin 3147 yields a derivative with enhanced antimicrobial activity

The lantibiotic lacticin 3147 consists of two ribosomally synthesized and post-translationally modified antimicrobial peptides, Ltnα and Ltnβ, which act synergistically against a wide range of Gram-positive microorganisms. We performed saturation mutagenesis of specific residues of Ltnα to determine...

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Detalhes bibliográficos
Main Authors: Field, Des, Molloy, Evelyn M, Iancu, Catalin, Draper, Lorraine A, O' Connor, Paula M, Cotter, Paul D, Hill, Colin, Ross, R Paul
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons Ltd 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918158/
https://ncbi.nlm.nih.gov/pubmed/23433070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/1751-7915.12041
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