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Fate of the Two-Component Lantibiotic Lacticin 3147 in the Gastrointestinal Tract

The component peptides of lacticin 3147 were degraded by α-chymotrypsin in vitro with a resultant loss of antimicrobial activity. Activity was also lost in ileum digesta. Following oral ingestion, neither of the lacticin 3147 peptides was detected in the gastric, jejunum, or ileum digesta of pigs, a...

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Bibliographische Detailangaben
Hauptverfasser: Gardiner, Gillian E., Rea, Mary C., O'Riordan, Brid, O'Connor, Paula, Morgan, Sheila M., Lawlor, Peadar G., Lynch, P. Brendan, Cronin, Michael, Ross, R. Paul, Hill, Colin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2074984/
https://ncbi.nlm.nih.gov/pubmed/17766459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01117-07
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