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Recombinant rabbit single-chain antibodies bind to the catalytic and C-terminal domains of HIV-1 integrase protein and strongly inhibit HIV-1 replication

The human immunodeficiency virus type 1 (HIV-1) integrase (IN) protein plays an important role during the early stages of the retroviral life cycle and therefore is an attractive target for therapeutic intervention. We immunized rabbits with HIV-1 IN protein and developed a combinatorial single-chai...

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Bibliografische gegevens
Hoofdauteurs: da Silva, Frederico Aires, Li, Min, Rato, Sylvie, Maia, Sara, Malhó, Rui, Warren, Kylie, Harrich, David, Craigie, Robert, Barbas, Carlos, Goncalves, Joao
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3917493/
https://ncbi.nlm.nih.gov/pubmed/23586912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bab.1034
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