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Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are distributed periportally in normal and mevinolin-treated rat livers.

Mevinolin is a potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase; EC 1.1.1.34), an enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis. We have been studying the hepatic distribution of reductase with immunofluorescence microscopy and liver u...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Singer, I I, Kawka, D W, Kazazis, D M, Alberts, A W, Chen, J S, Huff, J W, Ness, G C
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1984
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391745/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6382266/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.17.5556
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