Hydroxymethylglutaryl-coenzyme A reductase-containing hepatocytes are distributed periportally in normal and mevinolin-treated rat livers.

Mevinolin is a potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase; EC 1.1.1.34), an enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis. We have been studying the hepatic distribution of reductase with immunofluorescence microscopy and liver u...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Singer, I I, Kawka, D W, Kazazis, D M, Alberts, A W, Chen, J S, Huff, J W, Ness, G C
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1984
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391745/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6382266/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.17.5556
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