Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699.

A beta-lactone isolated from Fusarium sp. has been shown to be a potent specific inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase [(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating), EC, 4.1.3.5] from rat liver. The structure of this beta-lacto...

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Detalhes bibliográficos
Main Authors: Greenspan, M D, Yudkovitz, J B, Lo, C Y, Chen, J S, Alberts, A W, Hunt, V M, Chang, M N, Yang, S S, Thompson, K L, Chiang, Y C
Formato: Artigo
Idioma:Inglês
Publicado em: 1987
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC299321/
https://ncbi.nlm.nih.gov/pubmed/2890166
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