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Emerging Science of Hydroxyurea Therapy for Pediatric Sickle Cell Disease
Hydroxyurea is the sole approved pharmacologic therapy for sickle cell disease (SCD). Higher fetal hemoglobin (HbF) levels diminish de-oxygenated sickle globin polymerization in vitro and clinically reduce the incidence of disease morbidities. Clinical and laboratory effects of hydroxyurea largely r...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3917141/ https://ncbi.nlm.nih.gov/pubmed/24252885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2013.227 |
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