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Emerging Science of Hydroxyurea Therapy for Pediatric Sickle Cell Disease

Hydroxyurea is the sole approved pharmacologic therapy for sickle cell disease (SCD). Higher fetal hemoglobin (HbF) levels diminish de-oxygenated sickle globin polymerization in vitro and clinically reduce the incidence of disease morbidities. Clinical and laboratory effects of hydroxyurea largely r...

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Bibliografske podrobnosti
Main Authors: Green, Nancy S., Barral, Sandra
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3917141/
https://ncbi.nlm.nih.gov/pubmed/24252885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2013.227
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