Inhibition of DNA synthesis by an electrophilic metabolite of benzo[a]pyrene.

Mitogen-stimulated scheduled DNA synthesis and DNA excision repair in human lymphocytes, as well as DNA polymerase a activity in a cell-free system, were inhibited by an electrophilic metabolite of benzo[a]pyrene. This metabolite, (+/-)-anti-(7r,8t)-dihydroxy-(9,10t)-epoxy-7,8,9,10-tetrahyd robenzo[...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Busbee, D L, Joe, C O, Norman, J O, Rankin, P W
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1984
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391691/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6089190/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.17.5300
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