pH-Responsive Theranostic Polymer-Caged Nanobins (PCNs): Enhanced Cytotoxicity and T(1) MRI Contrast by Her2-Targeting

A PCN theranostic platform comprises a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with Herceptin and Gd(III)-based MRI contrast agents. In vitro testing reveals a 14-fold increase in DXR-based cytotoxicity versus a non-targeted analogue and an...

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Autori principali: Hong, Bong Jin, Swindell, Elden P., MacRenaris, Keith W., Hankins, Patrick L., Chipre, Anthony J., Mastarone, Daniel J., Ahn, Richard W., Meade, Thomas J., O’Halloran, Thomas V., Nguyen, SonBinh T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916701/
https://ncbi.nlm.nih.gov/pubmed/24516291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ppsc.201300158
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