Modular Polymer-Caged Nanobins as a Theranostic Platform with Enhanced Magnetic Resonance Relaxivity and pH-Responsive Drug-Release

‘Clickable’ polymer-caged nanobins enable the combination of Gd(III) MRI contrast agents and an anticancer drug (gemcitabine, GMC) into a single theranostic platform. The resulting Gd(III)-conjugated, GMC-loaded PCNs (Gd(III)-PCN(GMC)) exhibit significant enhancements in r(1) relaxivity, drug uptake...

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Autori principali: Lee, Sang-Min, Song, Ying, Hong, Bong Jin, MacRenaris, Keith W., Mastarone, Daniel J., O’Halloran, Thomas V., Meade, Thomas J., Nguyen, SonBinh T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096927/
https://ncbi.nlm.nih.gov/pubmed/21082634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201004867
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