Oxidation-induced Structural Changes of Ceruloplasmin Foster NGR Motif Deamidation That Promotes Integrin Binding and Signaling

Asparagine deamidation occurs spontaneously in proteins during aging; deamidation of Asn-Gly-Arg (NGR) sites can lead to the formation of isoAsp-Gly-Arg (isoDGR), a motif that can recognize the RGD-binding site of integrins. Ceruloplasmin (Cp), a ferroxidase present in the cerebrospinal fluid (CSF),...

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Main Authors: Barbariga, Marco, Curnis, Flavio, Spitaleri, Andrea, Andolfo, Annapaola, Zucchelli, Chiara, Lazzaro, Massimo, Magnani, Giuseppe, Musco, Giovanna, Corti, Angelo, Alessio, Massimo
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2014
主題:
Protein Structure and Folding
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3916571/
https://ncbi.nlm.nih.gov/pubmed/24366863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.520981
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