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Ceruloplasmin oxidized and deamidated by Parkinson's disease cerebrospinal fluid induces epithelial cells proliferation arrest and apoptosis

In Parkinson's disease, the ferroxidase ceruloplasmin (Cp) is oxidized and deamidated by the pathological cerebrospinal fluid (CSF) environment. These modifications promote the gain of integrin binding properties, fostered by the deamidation of two NGR-motifs present in the Cp sequence that con...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Barbariga, Marco, Zanardi, Alan, Curnis, Flavio, Conti, Antonio, Boselli, Daniela, Di Terlizzi, Simona, Alessio, Massimo
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7511351/
https://ncbi.nlm.nih.gov/pubmed/32968118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-72447-z
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