Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae.

Saccharomyces cerevisiae cells were transformed with plasmids containing hybrid genes in which the sequence encoding mature human epidermal growth factor was joined to sequences encoding the leader region (preprosegment) of the precursor of the yeast mating pheromone alpha-factor. These cells accura...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Brake, A J, Merryweather, J P, Coit, D G, Heberlein, U A, Masiarz, F R, Mullenbach, G T, Urdea, M S, Valenzuela, P, Barr, P J
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1984
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391546/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6087338/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.15.4642
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