Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae.

Saccharomyces cerevisiae cells were transformed with plasmids containing hybrid genes in which the sequence encoding mature human epidermal growth factor was joined to sequences encoding the leader region (preprosegment) of the precursor of the yeast mating pheromone alpha-factor. These cells accura...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Brake, A J, Merryweather, J P, Coit, D G, Heberlein, U A, Masiarz, F R, Mullenbach, G T, Urdea, M S, Valenzuela, P, Barr, P J
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 1984
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Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391546/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6087338/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.15.4642
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