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Gli protein activity is controlled by multi-site phosphorylation in vertebrate Hedgehog signaling

Gli proteins are transcriptional effectors of the Hedgehog (Hh) pathway in both normal development and cancer. We describe a program of multi-site phosphorylation that regulates the conversion of Gli proteins into transcriptional activators. In the absence of Hh ligands, Gli activity is restrained b...

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Detalhes bibliográficos
Main Authors: Niewiadomski, Pawel, Kong, Jennifer H., Ahrends, Robert, Ma, Yan, Humke, Eric W., Khan, Sohini, Teruel, Mary N., Novitch, Bennett G., Rohatgi, Rajat
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915062/
https://ncbi.nlm.nih.gov/pubmed/24373970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.12.003
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