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Automated NMR Fragment Based Screening Identified a Novel Interface Blocker to the LARG/RhoA Complex
The small GTPase cycles between the inactive GDP form and the activated GTP form, catalyzed by the upstream guanine exchange factors. The modulation of such process by small molecules has been proven to be a fruitful route for therapeutic intervention to prevent the over-activation of the small GTPa...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3914932/ https://ncbi.nlm.nih.gov/pubmed/24505392 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088098 |
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