Activation of Transcription Factor Nrf2 Signalling by the Sphingosine Kinase Inhibitor SKI-II Is Mediated by the Formation of Keap1 Dimers

BACKGROUND: Anti-oxidant capacity is crucial defence against environmental or endogenous oxidative stress. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that plays a key defensive role against oxidative and cytotoxic stress and cellular senescence. Howe...

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Main Authors: Mercado, Nicolas, Kizawa, Yasuo, Ueda, Keitaro, Xiong, Yeping, Kimura, Genki, Moses, Audric, Curtis, Jonathan M., Ito, Kazuhiro, Barnes, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914928/
https://ncbi.nlm.nih.gov/pubmed/24505412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088168
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