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Corticotropin-releasing factor-induced adrenocorticotropin hormone release and synthesis is blocked by incorporation of the inhibitor of cyclic AMP-dependent protein kinase into anterior pituitary tumor cells by liposomes.

Corticotropin-releasing factor (CRF) is the most potent and effective natural stimulant of corticotropin (ACTH) secretion. In a tumor cell line of the mouse anterior pituitary (AtT-20/D16-16) consisting of a homogeneous population of corticotrophs, CRF is known to increase adenylate cyclase and cAMP...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Reisine, T, Rougon, G, Barbet, J, Affolter, H U
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1985
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC391483/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2999799/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.23.8261
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