Corticotropin-releasing factor-induced adrenocorticotropin hormone release and synthesis is blocked by incorporation of the inhibitor of cyclic AMP-dependent protein kinase into anterior pituitary tumor cells by liposomes.

Corticotropin-releasing factor (CRF) is the most potent and effective natural stimulant of corticotropin (ACTH) secretion. In a tumor cell line of the mouse anterior pituitary (AtT-20/D16-16) consisting of a homogeneous population of corticotrophs, CRF is known to increase adenylate cyclase and cAMP...

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Autores principales: Reisine, T, Rougon, G, Barbet, J, Affolter, H U
Formato: Artigo
Lenguaje:Inglês
Publicado: 1985
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC391483/
https://ncbi.nlm.nih.gov/pubmed/2999799
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