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Escherichia coli Deletion Mutants Illuminate Trade-Offs between Growth Rate and Flux through a Foreign Anabolic Pathway

Metabolic engineers strive to improve the production yields of microbial fermentations, sometimes by mutating the genomes of production strains. Some mutations are detrimental to the health of the organism, so a quantitative and mechanistic understanding of the trade-offs could inform better designs...

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Détails bibliographiques
Auteurs principaux: Falls, Kelly C., Williams, Aimee L., Bryksin, Anton V., Matsumura, Ichiro
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913754/
https://ncbi.nlm.nih.gov/pubmed/24505410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088159
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