A Novel Angiotensin I-Converting Enzyme Mutation (S333W) Impairs N-Domain Enzymatic Cleavage of the Anti-Fibrotic Peptide, AcSDKP

BACKGROUND: Angiotensin I-converting enzyme (ACE) has two functional N- and C-domain active centers that display differences in the metabolism of biologically-active peptides including the hemoregulatory tetrapeptide, Ac-SDKP, hydrolysed preferentially by the N domain active center. Elevated Ac-SDKP...

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Hauptverfasser: Danilov, Sergei M., Wade, Michael S., Schwager, Sylva L., Douglas, Ross G., Nesterovitch, Andrew B., Popova, Isolda A., Hogarth, Kyle D., Bhardwaj, Nakul, Schwartz, David E., Sturrock, Edward D., Garcia, Joe G. N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913711/
https://ncbi.nlm.nih.gov/pubmed/24505347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088001
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