Vaccine-Induced IgG Antibodies to V1V2 Regions of Multiple HIV-1 Subtypes Correlate with Decreased Risk of HIV-1 Infection

In the RV144 HIV-1 vaccine efficacy trial, IgG antibody (Ab) binding levels to variable regions 1 and 2 (V1V2) of the HIV-1 envelope glycoprotein gp120 were an inverse correlate of risk of HIV-1 infection. To determine if V1V2-specific Abs cross-react with V1V2 from different HIV-1 subtypes, if the...

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Main Authors: Zolla-Pazner, Susan, deCamp, Allan, Gilbert, Peter B., Williams, Constance, Yates, Nicole L., Williams, William T., Howington, Robert, Fong, Youyi, Morris, Daryl E., Soderberg, Kelly A., Irene, Carmela, Reichman, Charles, Pinter, Abraham, Parks, Robert, Pitisuttithum, Punnee, Kaewkungwal, Jaranit, Rerks-Ngarm, Supachai, Nitayaphan, Sorachai, Andrews, Charla, O’Connell, Robert J., Yang, Zhi-yong, Nabel, Gary J., Kim, Jerome H., Michael, Nelson L., Montefiori, David C., Liao, Hua-Xin, Haynes, Barton F., Tomaras, Georgia D.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3913641/
https://ncbi.nlm.nih.gov/pubmed/24504509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0087572
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